Project Project Leader 1. Research on Prevention, Treatment and Rehabilitation Strategies for Mental Health Promotion Nozomu Asukai, MD, PhD 2. Research on the Pathogenesis of Dementing Disorders and Development of Disease-modifying Therapies Haruhiko Akiyama, MD, PhD 3. Research on the Pathophysiology and Treatment of Schizophrenia and Affective Disorders Masanari Itokawa, MD, PhD 4. Research on the Molecular and Systemic Actions of Addictive Substances for Clinical Application Kazutaka Ikeda, Ph.D. 5. Research on the Neural Mechanisms of "Kansei" and Its Visualization Yoko Hoshi, MD, PhD 6. Research on the Pathophysiology of Sleep Wake Disorders Makoto Honda, MD, PhD